Forskning

July 17, 2023

Association between Coffee and Incident Heart Failure: A Prospective Cohort Study from the UK Biobank

Q Han et al, 2023. Association between Coffee and Incident Heart Failure: A Prospective Cohort Study from the UK Biobank, Nutrition, Metabolism and Cardiovascular Disease.

ABSTRACT:

Background and Aims: The relationship between coffee consumption and heart failure (HF) incidence is inconclusive. This study aimed to explore the association between time-varying coffee consumption and incident HF using a longitudinal study design.

Methods and Results: Data were obtained from the UK Biobank, comprising 497,503 adults (age, 56.5±8.1 years; 54.6% women) who were free from HF at baseline in 2006–2010. The median follow-up time for the HF incidence was 11.9 years. Marginal structural models (MSM) were employed to adjust for potential time-varying confounders and account for bias caused by loss of follow-up. Furthermore, we used a restricted cubic spline to test and describe the nonlinear relationship between coffee consumption and HF risk. At baseline, 70.5% of participants reported drinking ≥1 cups/d coffee and 2.7% participants developed HF. After adjusting for potential confounders, we identified a nonlinear J-shaped association between coffee consumption and HF risk (P<0.001). Compared with drinking coffee <1 cups/d, 1–2 cups/d (HR=0.878; 95% CI: 0.838–0.920), 3–4 cups/d (HR=0.920; 95% CI: 0.869–0.974) may be associated with a reduced risk of HF, while >6 cups/d (HR=1.209; 95% CI: 1.056–1.385) may be associated with a higher risk of HF. However, sensitive analyses stratified by gender and smoking status indicated that >6 cups/d does not significantly increase the risk of HF. Additionally, the type of coffee was found to significant impact on the incidence of HF (P<0.05).

Conclusion: In this large cohort of UK adults, moderate coffee consumption may reduce risk of HF incidence.