October 1, 2013

13, Effects of coffee consumption, smoking, and hormones on risk for primary sclerosing cholangitis

I M Andersen et al, 2013, Effects of coffee consumption, smoking, and hormones on risk for primary sclerosing cholangitis, Clinical Gastroenterology and Hepatology, Accepted Manuscript.

Background & Aims: Little is known about nongenetic risk factors for primary sclerosing  cholangitis (PSC), except a possible protective effect of smoking. We investigated the  relationship between environmental risk factors and susceptibility to PSC.

Methods: A questionnaire was distributed to patients with PSC, recruited from Oslo  University  Hospital Rikshospitalet in Norway through 2011, and randomly chosen individuals from the  Norwegian Bone Marrow Donor Registry (controls). Data were analyzed from 240 patients  with PSC and 245 controls, matched for sex and age.

Results: A lower proportion of patients with PSC were daily coffee drinkers than controls,  both currently (76% vs 86%; odds ratio [OR], 0.52; 95% confidence interval [CI], 0.32–0.82;  P=.006) and at the age of 18 y (35% vs 49%; OR, 0.58; 95% CI, 0.40–0.83; P=.003). The  associations were mainly attributed to differences observed in men. Twenty percent of the  patients were ever (current or former) daily smokers compared with 43% of controls (OR,  0.33; 95% CI, 0.22–0.50; P<.001). Ever daily smoking before PSC diagnosis was associated  with older age at diagnosis (42 y vs 32 y, P<.001). Ever daily smoking (P<.001) and being a  coffee drinker at the age of 18 y (P=.048) were independently and negatively associated with  PSC. Fewer female patients with PSC than controls reported ever use of hormonal  contraception (51% vs 85%, P<.001). Among female patients, there was a strong correlation  between increasing number of children before the diagnosis of PSC and increasing age at  diagnosis (r=0.63; P<.001).

Conclusions: Coffee consumption and smoking might protect against development of PSC.  In women, the disease might be influenced by hormonal factors.

Modtag nyhedsbrev

Ja tak, jeg vil gerne modtage nyhedsbrev, når der er noget nyt om kaffe og helbred.