Forskning

September 17, 2011

Coffee Consumption and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies

S C Larsson and N Orsini, Coffee Consumption and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies, American Journal of Epidemiology, 2011.

Coffee consumption has been inconsistently associated with risk of stroke. These authors conducted a meta-analysis of prospective studies to quantitatively assess the association between coffee consumption and stroke risk. Prospective studies in which investigators reported relative risk of stroke for 3 or more categories of coffee consumption were eligible. Results from individual studies were pooled using a random-effects model. Eleven prospective studies, with 10,003 cases of stroke and 479,689 participants met the criteria for inclusion. There was some evidence of a nonlinear association between coffee consumption and risk of stroke. Compared with no coffee consumption, the relative risks of stroke were 0.86 for 2 cups of coffee per day, 0.83 for 3-4 cups of coffee per day, 0.87 for 6 cups a day, and 0.93 for 8 cups per day. These authors conclude that, ‘Findings from this meta-analysis indicate that moderate coffee consumption may be weakly inversely associated with risk of stroke’.