Forskning

November 8, 2019

Acute coffee ingestion with and without medium chain triglycerides decreases blood oxidative stress markers and increases ketone levels

M J McAllister et al, 2019. Acute coffee ingestion with and without medium chain triglycerides decreases blood oxidative stress markers and increases ketone levels, Canadian Journal of Physiology & Pharmacology, published online.

ABSTRACT:

BACKGROUND: Ingestion of ketone supplements, caffeine and medium chain triglycerides (MCTs) may all be effective strategies to increase blood levels of the ketone body beta-hydroxybutyrate (D-BHB). However, acute ingestion of a bolus of lipids may increase oxidative stress (OS). The purpose of the study was to investigate the impact of adding varying amounts of MCTs to coffee on blood levels of D-BHB and markers of OS.

METHODS: Ten college-aged men ingested coffee with 0g, 28g, and 42g of MCT in a randomized order. Blood samples were collected pre, as well as two and four hours postprandial and analyzed for D-BHB, total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), glucose, triglycerides (TAG), insulin, as well as OS markers: advanced oxidation protein products (AOPP), glutathione (GSH), malondialdehyde (MDA), and hydrogen peroxide (H2O2).

RESULTS: All three treatments resulted in a significant increase in D-BHB, HDL-c, and TC, as well as a significant decrease in TAG, MDA, H2O2, and insulin. The 42g treatment was associated with significantly higher levels of AOPP and MDA.

CONCLUSIONS: Acute ingestion of coffee results in favorable changes to markers of cardiometabolic health that were not impacted by the addition of 28g MCT. However, 42g MCT caused significantly greater OS.