Forskning
January 11, 2013
EEffects of caffeine on the Inflammatory response induced by a 15-Km run competition
P Tauler et al, 2013, Effects of caffeine on the Inflammatory response induced by a 15-Km run competition, Medicine and Science in Sports and Exercise, Accepted Manuscript.
ABSTRACT
Purpose: 1) To determine the effects of caffeine supplementation on the inflammatory response (IL-6 and IL-10 levels and leukocyte numbers) induced by a 15 Km run competition and 2) to examine the effect of caffeine supplementation on the energetic metabolites as well as on the exercise induced oxidative stress. Methods: A double-blind study of supplementation with caffeine was performed. Athletes participating in the study (n=33) completed a 15-Km run competition. Before competition athletes took 6 mg/kg body weight of caffeine (caffeine group, n=17) or a placebo (placebo group, n=16). Blood samples were taken before and after competition (immediately after two hours recovery). Leukocyte numbers were determined in blood. Concentrations of oxidative stress markers, antioxidants, interlukins (IL-6 and IL-10), caffeine, adrenaline and energetic metabolites were measured in plasma or serum. Results: Caffeine supplementation induced higher increases in circulating total leukocytes and neutrophils, with significant differences between groups after recovery. Adrenaline, glucose and lactate levels increased after exercise, with higher increases in the caffeine group. Exercise induced significant increases in IL-6 and IL-10 plasma levels, with higher increases in the caffeine group. Caffeine supplementation induced higher increases in oxidative stress markers after the competition. Conclusion: Caffeine supplementation induced higher levels of IL-6 and IL-10 in response to exercise, enhancing the anti-inflammatory response. The caffeine induced increase in adrenaline could be the ** responsible for the higher increase in IL-6 levels, as well as for the increased lactate levels. Furthermore, caffeine seems to enhance oxidative stress induced by exercise.
**word missing in manuscript
