Forskning

February 14, 2020

Inter-individual variation in cancer and cardiometabolic health outcomes in response to coffee consumption: a critical review

E Visser et al, 2020. Inter-individual variation in cancer and cardiometabolic health outcomes in response to coffee consumption: a critical review, Mol Nutr Food Res, published online.

ABSTRACT:

Scope: Coffee has been associated with a lower risk of cancer, cardiovascular disease and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review we systematically evaluated determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption. Methods and results: Embase and MEDLINE were searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies met the inclusion criteria, which reported variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. Our qualitative analysis showed that sex, BMI, smoking, alcohol intake, menopausal status and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit that the majority of studies had insufficient statistical power to detect significant interaction between these factors and coffee consumption. Conclusion: We identified several genetic and non-genetic determinants of inter-individual variability in the responses to coffee and caffeine consumption, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects.