Forskning

January 9, 2013

The effects of physiological concentration of caffeine on the endurance of maximally and submaximally stimulated mouse soleus muscle

J Tallis et al, 2013, The effects of physiological concentration of caffeine on the endurance of maximally and submaximally stimulated mouse soleus muscle, J Physiol Sci, published online ahead of print.

ABSTRACT
The use of caffeine as an ergogenic aid to promote endurance has been widely studied, with human literature showing the greatest benefit during submaximal muscle activities. Recent evidence suggests that the acute treatment of skeletal muscle with physiological concentrations of caffeine (70μlM maximum) will directly potentiate force production. The aims of the present study are: firstly, to assess the effects of a physiological concentration (70 lM) of caffeine on endurance in maximally activated mouse soleus (relatively slow) muscle; and secondly, to examine whether endurance changes when muscle is activated submaximally during caffeine treatment. Maximally stimulated soleus muscle treated with 70 μM caffeine resulted in a significant (17.6 %) decrease in endurance. In contrast, at a submaximal stimulation frequency, caffeine treatment significantly prolonged endurance (by 19.2 %). Findings are activation-dependent such that, during high frequency stimulation, caffeine accelerates fatigue, whereas, during low frequency stimulation, caffeine delays fatigue.