Forskning

April 30, 2014

Insights on the antitumour effects of kahweol on human breast cancer: decreased survival and increased production of reactive oxygen species and cytotoxicity

C Cardenas et al, 2014, Insights on the antitumour effects of kahweol on human breast cancer: decreased survival and increased production of reactive oxygen species and cytotoxicity, Biochemical and Biophysical Research Communications, Accepted Manuscript,

published online ahead of print.

Laboratory Study – Breast Cancer

ABSTRACT: The present study aims to identify the modulatory effects of kahweol, an antioxidant diterpene present in coffee beans, on a panel of human tumor cell lines. Kahweol inhibits tumor cell proliferation and clonogenicity and induces apoptosis in several kinds of human tumor cells. In the estrogen receptor‐negative MDA‐MB231 human breast cancer, the mentioned effects are accompanied by caspases 3/7 and 9 activation and cytochrome c release. On the other hand, kahweol increases the production of reactive oxygen species and their cytotoxicity in human breast cancer cells but not in normal cells. Taken together, our data suggest that kahweol is an antitumor compound with inhibitory effects on tumor cell growth and survival, especially against MDA‐MB231 breast cancer cells.