Forskning

August 9, 2013

Stimulation of postprandial fat utilization in healthy humans by daily consumption of chlorogenic acid

S Soga et al, 2013, Stimulation of postprandial fat utilization in healthy humans by daily consumption of chlorogenic acid, Biosc. Biotechnol. Biochem, Volume 77 (8) Advance View Proofs 

ABSTRACT:
Long-term ingestion of coffee polyphenols (chlorogenic acids, CGAs) reduces body fat in humans and rodents. While CGA supplementation has been shown to increase fat utilization in rodents, evidence in humans is still limited. The present study clarifies the effect of daily CGA consumption on energy metabolism in humans. Eighteen health male subjects (36.1 ± 7.4 years of age) participated in a placebo controlled, double-blind, crossover, intervention study with two different test beverages. The subjects consumed 185 mL of a test beverage with or without CGAs (329 mg) daily for 4 wk. The energy metabolism was evaluated by using indirect calorimetry before and after the test period during fasting and up to 180 min postprandially. Indirect calorimetry showed that a 4-wk ingestion of the CGA beverage led to a significantly higher postprandial energy expenditure than that of the control beverage. The subjects ingesting the CGA beverage exhibited higher postprandial fat utilization than those consuming the control beverage. The daily CGA consumption therefore increased postprandial fat utilization in healthy humans.