Forskning

August 30, 2014

Association of coffee drinking with all‐cause mortality: a systematic review and meta‐analysis

Y Zhao et al, 2014, Association of coffee drinking with all‐cause mortality: a systematic review and meta‐analysis, Public Health Nutrition, published online ahead of print.

Meta‐analysis – All Cause Mortality

ABSTRACT: Objective: We aimed to use the meta‐analysis method to assess the relationship between coffee drinking and all‐cause mortality. Design: Categorical and dose response meta‐analyses were conducted using random‐effects models. SETTING: We systematically searched and identified eligible literature in the PubMed and Scopus databases. Subjects: Seventeen studies including 1 054 571 participants and 131 212 death events from all causes were included in the present study. Results: Seventeen studies were included and evaluated in the meta‐analysis. A U‐shaped dose‐response relationship was found between coffee consumption and all‐cause mortality (P for non‐linearity <0∙001). Compared with non/occasional coffee drinkers, the relative risks for all‐cause mortality were 0∙89 (95 % CI 0∙85, 0∙93) for 1‐<3 cups/d, 0∙87 (95 % CI 0∙83, 0∙91) for 3‐<5 cups/d and 0∙90 (95 % CI 0∙87, 0∙94) for ≥5 cups/d, and the relationship was more marked in females than in males. Conclusions: The present meta‐analysis of prospective cohort studies indicated that light to moderate coffee intake is associated with a reduced risk of death from all causes, particularly in women.