December 3, 2013
K S Furtado et al, 2013, Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine, Food and Chemical Toxicology, published online ahead of print.
Coffee has been inversely related to the incidence of human liver disease; however, whether caffeine is the component responsible for the beneﬁcial effects of coffee remains controversial. This study evaluated the beneﬁcial effects of coffee or caffeine in a medium-term bioassay for rat liver ﬁbrosis/carcinogenesis induced by diethylnitrosamine (DEN) and carbon tetrachloride (CCl4). One week after the DEN injection, the groups started to receive conventional coffee, instant coffee or 0.1% caffeine ad libitum for 24 weeks.
The groups receiving conventional coffee or caffeine presented a signiﬁcant reduction in collagen content and mRNA expression of collagen I. The groups receiving instant coffee or caffeine had a signiﬁcant reduction in the size and area of pre-neoplastic lesions and in the mean number of neoplastic lesions. A significant increase in liver bax protein levels was observed in the groups receiving instant coffee or caffeine as compared to the control group. These data indicate that the most pronounced hepatoprotective effect against ﬁbrosis was observed in the groups receiving conventional coffee and 0.1% caffeine, and the greatest effects against liver carcinogenesis were detected in the groups receiving instant coffee and 0.1% caffeine.
Ja tak, jeg vil gerne modtage nyhedsbrev, når der er noget nyt om kaffe og helbred.