Forskning

September 30, 2013

Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a meta-analysis

J Cheng et al, 2013, Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a meta-analysis, American Journal of Obstetrics and Gynecology, published online ahead of print.

ABSTRACT:

OBJECTIVE: This study was undertaken to explore the association between maternal coffee consumption during pregnancy and childhood acute leukemia (AL).

STUDY DESIGN: The PubMed database was used to search studies up to May 5, 2013 and the lists of references of retrieved articles were also screened to identify additional relevant studies. Studies were included if they reported the odds ratio (OR) and corresponding 95% confident interval (CI) of childhood AL, including childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), with respect to maternal coffee consumption during pregnancy.

RESULTS: Compared with non/lowest drinkers, the combined OR regarding the relationship of maternal coffee consumption during pregnancy and childhood AL was 1.22 (95% CI, 1.04-1.43) for ever drinkers, 1.16 (95% CI, 1.00-1.34) for low to moderate drinkers and 1.72 (95% CI, 1.37-2.16) for high drinkers. When analysis was conducted by subtypes of childhood AL, maternal coffee consumption (high drinkers vs non/lowest drinkers) were statistically significant associated with childhood ALL (1.65, 95% CI, 1.28-2.12) and childhood AML (1.58, 95% CI, 1.20-2.08). We observed the linear dose-response relationship of coffee consumption and childhood AL (P for nonlinearity=0.68), including childhood ALL and childhood AML, with the increased coffee consumption, the risk of childhood AL increased.

CONCLUSION: The findings of the meta-analysis suggest that maternal coffee consumption during pregnancy may increase the risk of childhood AL. Because of limited studies, further prospective studies are urgently needed to explore the adverse effect of coffee consumption on childhood AL.