Forskning

August 30, 2014

Blood pressure in relation to coffee and caffeine consumption

I Guessous et al, 2014, Blood pressure in relation to coffee and caffeine consumption, Current Hypertension Reports, published online ahead of print.

Review Paper – Blood Pressure

ABSTRACT: The relationship between blood pressure (BP) and coffee is of major interest given its widespread consumption and the public health burden of high BP. Yet, there is no specific recommendation regarding coffee intake in existing hypertension guidelines. The lack of a definitive understanding of the BP‐coffee relationship is partially attributable to issues that we discuss in this review, issues such as acute vs. chronic effects, genetic and smoking effect modifications, and coffee vs. caffeine effects. We also present evidence from meta‐analyses of studies on the association of BP with coffee intake. The scope of this review is limited to the latest advances published with a specific focus on caffeine, acknowledging that caffeine is only one among numerous components in coffee that may influence BP. Finally, considering the state of the research, we propose a mechanism by which the CYP1A2 gene and enzyme influence BP via inhibition of the adenosine receptor differentially in smokers and non‐smokers. In the conclusion the authors state that: ‘In our view, there is currently no evidence to suggest that people with high BP should refrain from consuming caffeinated beverages when taken in reasonable amounts. On the contrary, coffee intake seems to be associated with decreased mortality in general and caffeinated beverages seem to be associated with lower risk of high BP in non‐smokers’.