Forskning

September 15, 2011

Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: A randomized controlled trial

N M Wedick et al (includes R Van Dam and Frank Hu) Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: A randomized controlled trial, Nutrition Journal, 2011, Volume 10.

The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes. This was a randomized parallel-arm intervention conducted in 45 healthy overweight volunteers who were non-smokers and regular coffee consumers. Participants were assigned to consumption of 5 cups (177 mL each) per day of instant caffeinated coffee, decaffeinated coffee, or no coffee (i.e., water) for 8 weeks. Compared with consuming no coffee, consumption of caffeinated coffee increased adiponectin and interlukin-6 concentrations and consumption of decaffeinated coffee decreased fetuin-A concentrations. For measures of glucose tolerance, insulin sensitivity, and insulin secretion, no significant differences were found between treatment groups. These authors concluded, ‘Although no changes in glycemia and/or insulin sensitivity were observed after 8 weeks of coffee consumption, improvements in adipocyte and liver function as indicated by changes in adiponectin and fetuin-A concentrations may contribute to beneficial metabolic effects of long-term coffee consumption’.