Forskning

August 2, 2011

Increase in blood pressure and heart rate induced by caffeine are inhibited by (-)-Epigallocatechin-3-O-gallate: Involvement of catecholamine

J-Y Han et al, Increase in blood pressure and heart rate induced by caffeine are inhibited by (-)-Epigallocatechin-3-O-gallate: Involvement of catecholamines, Journal of Cardiovascular Pharmacology, 2011.

In a previous experiment, (-)-epigallocatechin-3-O-gallate (EGCG) reduced caffeine induced locomotor activity and stereotyped behaviours and inhibited caffeine-induced neuronal stimulant activity. This research was performed to give additional evidence that EGCG counteracts caffeine-induced stimulant effects in animals. EGCG inhibited caffeine-induced cardiovascular activation measures, such as arterial pressure and heart rate. In addition, the increase in the levels of adrenaline and noradrenaline in the blood induced by caffeine were reduced by EGCG. ‘We suggest that EGCG may reduce caffeine-induced increases in blood pressure and heart rate and may decrease catecholamine levels in the blood. Therefore, EGCG counteracts caffeine-induced cardiovascular activity. The stimulant effects of caffeine should be reduced by the amount of EGCG in green tea’.