Forskning
March 11, 2015
Habitual coffee intake and genetic polymorphisms, and type 2 diabetes
J K Lee et al, 2015, Habitual coffee intake and genetic polymorphisms, and type 2 diabetes, European Journal of Endocrinology, published online ahead of print.
Abstract
Background: The association between coffee intake and type 2 diabetes may be modulated by common genetic variation. Objective: The purpose of this study was to examine the association between habitual coffee intake and the risk of type 2 diabetes and to determine whether this association varies by genetic polymorphisms related to type 2 diabetes in Korean adults. Design and Methods: A population-based cohort study over a follow-up of 4 years was conducted. A total of 4,077 Korean men and women aged 40-69 years with a normal glucose level at baseline were included. Coffee intake was assessed using a validated food frequency questionnaire and incident type 2 diabetes or pre-diabetes was defined by oral glucose tolerance test or fasting blood glucose test. The genomic DNA samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 5.0 and 9 single nucleotide polymorphisms related to type 2 diabetes in East Asian populations were extracted. Results: A total of 120 cases of type 2 diabetes and 1,128 cases of pre-diabetes were identified. After adjustment for potential confounding factors, we observed an inverse association, but without any clear linear trend, between coffee intake and the combined risk of type 2 diabetes and pre-diabetes. We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and pre-diabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11. Conclusion: We found a lower risk of pre-diabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215 which are known to be related to type 2 diabetes in East Asians.
