July 11, 2013
T S Chen & F Y Chang, 2013, Elevated serum dopamine increases while coffee consumption decreases the occurrence of reddish streaks in intact stomach, Journal of Gastroenterology and Hepatology, published online ahead of print.
Background and Aim: Reddish streaks in an intact stomach are an endoscopic feature of duodenogastric reflux. This study aimed to identify which factors are associated with gastric reddish streaks and thus help prevent mucosal damage from duodenogastric reflux. Methods: Demographic data, personal habits, stressful life events, and psychological distress were compared between subjects with only gastric reddish streaks and those with normal mucosa who underwent upper GI endoscopy as part of a self-paid physical check-up. Stress hormones dopamine and cortisol were also checked by HPLC and RIA methods respectively. Results: There were 95 subjects with gastric reddish streaks and 52 subjects with normal mucosa. No significant differences in age, gender, blood groups, education levels, marital status, religion, aspirin or NSAID use, smoking habit, alcohol consumption and intake of tea was found between the two groups, but intake of coffee was borderline more common in subjects with normal mucosa (38.5% vs. 22.1%, p=0.055). Subjects with gastric reddish streaks had lower H. pylori infection rate (37.8% vs. 19.3%, P<0.05). There were no significant differences in psychological distress and stressful life events between the two groups. Multivariate analysis shows that serum dopamine concentrations (odds ratio=11.31, 95% CI=2.11-60.48, p=0.005) and being without the consumption of coffee (OR=2.97, 95% CI=1.27-6.94, p=0.012) were associated with gastric reddish streaks. Conclusions: Elevated serum dopamine and less coffee consumption are associated with gastric reddish streaks. These findings implicate that increased dopamine level plays a role for abnormal duodenogastric reflux.
Ja tak, jeg vil gerne modtage nyhedsbrev, når der er noget nyt om kaffe og helbred.