June 2, 2015

A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy

J Li et al, 2015, A meta-analysis of risk of pregnancy loss and caffeine and coffee consumption during pregnancy, International Journal of Gynecology & Obstetrics, published online ahead of print.


BACKGROUND: Previous reports of the relationship between pregnancy loss and caffeine/coffee consumption have been inconsistent.

OBJECTIVES: To evaluate the association between pregnancy loss and caffeine and coffee consumption.
SEARCH STRATEGY: PubMed was searched for reports published before September 2014, with the keywords “caffeine,” “coffee,” “beverage,” “miscarriage,” “spontaneous abortion,” and “fetal loss.”

SELECTION CRITERIA: Case-control and cohort studies were included when they had been reported in English, the exposure of interest was caffeine/coffee consumption during pregnancy, the outcome of interest was spontaneous abortion or fetal death, and multivariate-adjusted odds ratios (ORs) or risk ratios were provided or could be calculated.

DATA COLLECTION AND ANALYSIS: Data were extracted and combined ORs calculated.

MAIN RESULTS: Overall, 26 studies were included (20 of caffeine and eight of coffee). After adjustment for heterogeneity, caffeine consumption was associated with an increased risk of pregnancy loss (OR 1.32, 95% confidence interval [CI] 1.24-1.40), as was coffee consumption (OR 1.11, 95% CI 1.02-1.21). A dose-response analysis suggested that risk of pregnancy loss rose by 19% for every increase in caffeine intake of 150mg/day and by 8% for every increase in coffee intake of two cups per day.

CONCLUSIONS: Consumption of caffeine and coffee during pregnancy seems to increase the risk of pregnancy loss.

Modtag nyhedsbrev

Ja tak, jeg vil gerne modtage nyhedsbrev, når der er noget nyt om kaffe og helbred.