Forskning

March 20, 2018

An insight into the therapeutic potential of major coffee components

M T Islam et al, 2018. An insight into the therapeutic potential of major coffee components, Current Drug Metabolism, Volume 19.

ABSTRACT:

The popular drink, coffee (Coffea arabica) is under the great attention of late because of its promising pharmacological potential. Caffeine (the major constituent of coffee) is known for its prominent psychoactive impact. This review aims at highlighting the therapeutic potentials of caffeine and other five coffee components viz. caffeic acid, chlorogenic acids, cafestol, ferulic acid and kahweol and their suggested mechanisms of action. A number of pharmacological activities are attributed to these components that include anti-oxidant, anti-inflammatory, immunomodulatory, anti-microbial, anti-cancer, cardioprotective and neuroprotective effects. In addition, osteogenesis (kahweol), anti-diabetic (caffeine, chlorogenic acid, and ferulic acid) and hepatoprotective (chlorogenic acid) activities have also been reported by some of these components in the scientific literature. On the other hand, caffeine has also been noted for adverse effect on the development of the brain at early stages and reproductive systems. In conclusion, more pre-clinical and clinical trials are recommended to investigate the safety profiles of these coffee components.