Forskning
February 20, 2012
Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)- Germany study
A Floegel et al, Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)- Germany study, American Journal of Clinical Nutrition, 2012, published online ahead of print.
ABSTRACT
Background: Early studies suggested that coffee consumption may increase the risk of chronic disease.
Objective: We investigated prospectively the association between coffee consumption and the risk of chronic diseases, including type 2 diabetes (T2D), myocardial infarction (MI), stroke, and cancer.
Design: We used data from 42,659 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)–Germany study. Coffee consumption was assessed by self-administered food frequency questionnaire at baseline, and data on medically verified incident chronic diseases were collected by active and passive follow-up procedures. HRs and 95% CIs were calculated with multivariate Cox regression models and compared by competing risk analysis.
Results: During 8.9 y of follow-up, we observed 1432 cases of T2D, 394 of MI, 310 of stroke, and 1801 of cancer as first qualifying events. Caffeinated (HR: 0.94; 95% CI: 0.84, 1.05) or decaffeinated(HR: 1.05; 95% CI: 0.84, 1.31) coffee consumption (>4 cups/d compared with <1 cup/d; 1 cup was defined as 150 mL) was not associated with the overall risk of chronic disease. A lower risk of T2D was associated with caffeinated (HR: 0.77; 95% CI: 0.63,0.94; P-trend 0.009) and decaffeinated (HR: 0.70; 95% CI: 0.46, 1.06; P-trend: 0.043) coffee consumption (>4 cups/d compared with <1 cup/d), but cardiovascular disease and cancer risk were not. The competing risk analysis showed no significant differences between the risk associations of individual diseases.
Conclusion: Our findings suggest that coffee consumption does not increase the risk of chronic disease, but it may be linked to a lower risk of T2D.
Floegel A et al (2012). Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) – Germany Study. Available at http://www.ajcn.org/content/early/2012/02/14/ajcn.111.023648.abstract
