Forskning

January 11, 2022

Adenosine A 2A Receptor Occupancy by Caffeine After Coffee Intake in Parkinson’s Disease

K Ishibashi et al, 2022. Adenosine A _2A Receptor Occupancy by Caffeine After Coffee Intake in Parkinson’s Disease, Movement Disorders, 

ABSTRACT:

Background: Coffee intake can decrease the risk for Parkinson’s disease (PD). Its beneficial effects are allegedly mediated by caffeine through adenosine A_2A receptor (A_2A R) antagonist action.

Objective: We aimed to calculate occupancy rates of striatal A_2A Rs by caffeine after coffee intake in PD.

Methods: Five patients with PD underwent ¹¹ C-preladenant positron emission tomography scanning at baseline and after intake of coffee containing 129.5 mg (n = 3) or 259 mg (n = 2) of caffeine. Concurrently, serum caffeine levels were measured.

Results: The mean serum caffeine level (μg/mL) was 0.374 at baseline and increased to 4.48 and 8.92 by 129.5 and 259 mg of caffeine, respectively. The mean occupancy rates of striatal A_2A Rs by 129.5 and 259 mg of caffeine were 54.2% and 65.1%, respectively.

Conclusions: A sufficient A_2A R occupancy can be obtained by drinking a cup of coffee, which is equivalent to approximately 100 mg of caffeine. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.