Forskning

April 30, 2012

Antiangiogenic properties of cafestol, a coffee diterpene, I human umbilical vein endothelial cells

S Wang et al, 2012, Antiangiogenic properties of cafestol, a coffee diterpene, I human umbilical vein endothelial cells, Biochemical and Biophysical Research Communications, Article in Press.

As angiogenesis plays important roles in tumor growth and metastasis, searching for antiangiogenic compounds is a promising tactic for treating cancers. Cafestol, a diterpene found mainly in unfiltered coffee, provides benefit through varied biological activity, including antitumorigenic, antioxidative, and anti-  inflammatory effects. This study aimed to investigate the effects of cafestol on angiogenesis and to  uncover the associated mechanism. We show that cafestol inhibits angiogenesis of human umbilical  vascular endothelial cells. This inhibition affects the following specific steps of the angiogenic process: proliferation, migration, and tube formation. The inhibitory effects of cafestol are accompanied by decreasing phosphorylation of FAK and Akt and by a decrease in nitric oxide production. Overall, cafestol inhibits angiogenesis by affecting the angiogenic signaling pathway.