Forskning
September 27, 2011
Coffee, caffeine, and risk of depression among women
M Lucas et al, Coffee, caffeine, and risk of depression among women, Archives of Internal Medicine, 2011, Volume 171.
A total of 50,739 US women free of depressive symptoms at baseline in 1996, were followed-up prospectively through to June 2006. Consumption of caffeine was measured from validated questionnaires completed from 1stMay 1980 through until April 1st 2004 and computed as cumulative mean consumption with a 2-year latency period applied. Clinical depression was defined as self-reported physician-diagnosed depression and antidepressant use. Relative risks of clinical depression were estimated using Cox proportional hazards regression models. During the ten years of follow up (1996-2006), 2607 cases of depression were identified. Compared with women consuming 1 or less cup of caffeinated coffee per week, the multivariate relative risk of depression was 0.85 for those consuming 2 to 3 cups per day and 0.80 for those consuming 4 cups per day or more. Multivariate relative risk of depression was 0.80 for women in the highest ( > 550 mg/d) versus lowest (<100 mg/d) of the 5 caffeine consumption categories. Decaffeinated coffee was not associated with depression risk.
