Forskning

March 28, 2013

Pharmacokinetics of caffeine following a dingle administration of coffee enema versus oral coffee consumption in healthy male subjects

S Teekachunhatean et al, 2013, Pharmacokinetics of caffeine following a dingle administration of coffee enema versus oral coffee consumption in healthy male subjects, ISRN Pharmacology, published online ahead of print.

ABSTRACT
The objective of this study was to determine the pharmacokinetics of caffeine after single administration of a coffee enema versus coffee consumed orally in healthy male subjects. The study design was an open-label, randomized two-phase crossover study. Eleven healthy subjects were randomly assigned either to receive 500mL of coffee enema for 10 minutes or to consume 180mL of ready to- drink coffee beverage. After a washout period of at least 10 days, all the subjects were switched to receive the alternate coffee procedure. Blood samples were collected immediately before and at specific time points until 12 hours after coffee administration in each phase. The mean caffeine content in both the coffee solution prepared for the coffee enema and the ready-to-drink coffee beverage was not statistically different. The