Forskning

June 17, 2016

Cautionary optimism: caffeine and Parkinson’s disease risk

L L Sokol et al, 2016, Cautionary optimism: caffeine and Parkinson’s disease risk, Journal of Clinical Movement Disorders, published online ahead of print.

ABSTRACT
Most Parkinson’s disease (PD) patients present without known family history and without a diagnosed prodromal phase, underscoring the difficulty of employing primary (neuroprevention) and secondary (neuroprotection) preventions. In cases of monogenic forms, however, potential gene-carrying family members of a proband could engage in neuroprevention, such as exercise or diet modifications, to attenuate the risk of, or delay, disease development. However, a historical lack of recognized disease-modifying interventions has limited clinicians’ ability to recommend reliable preventive measures in caring for at-risk populations. We briefly analyze the first retrospective study to examine caffeine consumption and PD risk in a LRRK2 R1628P cohort.