Forskning

April 20, 2012

Cigarette smoking, coffee drinking, and ingestion of charcoal-broiled beef as potential modifiers of drug therapy and confounders of clinical trials,

A H Conney et al, Cigarette smoking, coffee drinking, and ingestion of charcoal-broiled beef as potential modifiers of drug therapy and confounders of clinical trials, Journal of Pharmacology and Experimental Therapeutics, 2012, published online ahead of print.

ABSTRACT
A pathway of research is described leading from the finding of an inhibitory effect of 3-methylcholanthrene on the carcinogenicity of an aminoazo dye, to the induction of drug metabolizing enzymes by 3-methylcholanthrene, benzo [a]pyrene and other polycyclic aromatic hydrocarbons to the demonstration of enhanced drug metabolism in cigarette smokers, coffee drinkers and in people eating charcoal-broiled beef. The results of these studies indicate that cigarette smoking, coffee drinking and the ingestion of charcoal broiled beef (all result in exposure to polycyclic aromatic hydrocarbons) can influence the dosing regimen needed for proper drug therapy and are potential confounders of clinical trials with drugs metabolized by polycyclic aromatic hydrocarbon-inducible enzymes.